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Most guitar players have experienced the frustration of tuning a guitar via the standard 5th fret method only to find the guitar still slightly out of tune. The best way to tune is by using harmonics. All notes on the guitar contain a harmonic overtone. This tone confuses the ear drum because it is different than the actual note. Harmonics isolate the note's overtone so that one can hear the notes better. When you synchronize the overtones, the strings will all be in perfect tune.