Human growth hormone or somatotropin (HGH) is a peptide (protein-based) hormone produced by the anterior lobe of the pituitary gland. HGH binds to muscle, tendons, bones and every major organ of the human body. Growth hormone has a role in regenerating tissue, growth, repair, and healthy metabolism. Since HGH declines 50 percent every seven years after the age of 18-25, it may hold the key to anti-aging medicine. Rather than taking synthetic HGH, you can naturally enhance your own body's production of endogenous growth hormone through supplementation with a few targeted substances.
L-Arginine and L-Lysine
In 1981 study at the University of Rome, the combination of L-arginine and L-lysine was shown to increase growth hormone significantly in young test subjects. Further, an interview with Jeff "The Muscle Nerd" Anderson, a best-selling fitness author, explains that the two amino acids should be combined to enhance their effects. The L-lysine is said to help "piggyback" L-arginine across the blood-brain barrier.
According to "Natural Anabolics" by Jerry Brainum, gamma aminobutyric acid (GABA) can enhance growth hormone production when taken before intense exercise. However, GABA does have a sedative effect, so it may cause sleepiness in some individuals. Jeff Anderson recommends up to five grams of GABA taken before bed to enhance GH production.
"Homemade Supplement Secrets" by Jeff Anderson recommends 1.5 to 9 milligrams (age-dependent) of melatonin before bed to enhance GH production. "Natural Anabolics" further confirms this by citing studies in which melatonin was shown to increase growth hormone production during intense exercise. Melatonin can have a sedative effect, much like GABA, and should be taken with caution.
Many athletes and training enthusiasts use glutamine to speed up recovery after intense exercise. In addition, L-glutamine may help coax the pituitary gland into releasing more growth hormone. Even doses as small as one gram may significantly enhance GH in training athletes.
CDP-Choline increases the production of essential neurotransmitters related to GH enhancement, such as serotonin and dopamine. According to the Life Extension Foundation, CDP-Choline was shown to increase serum GH levels fourfold in healthy elderly adults.