Side Effects of Glucosamine and MSM


MSM’s long name is methylsulphonylmethane, but you may find it listed under a host of synonyms. The same is true for glucosamine. Glucosamine is manufactured as a sulfate, hydrochloride and chlorohydrate and combined with MSM and other supplements.


Glucosamine in any form may thin blood, so use caution if you are taking blood thinners such as Warfarin or have a bleeding disorder. MSM has no known interactions with drugs or other supplements.

Common Effects

The list of common physical side effects from using glucosamine include an upset stomach, headaches, sun sensitivity, tougher nails, insomnia, drowsiness and skin reactions. The side effects for MSM are similar and include nausea, fatigue, bloating, headache and itching.

Rare Effects

Rare side effects reported from glucosamine use are flatulence, diarrhea, constipation, heartburn, nausea, abdominal pain, loss of appetite and occasional vomiting. Women who are pregnant or breastfeeding should not use glucosamine and, as a precaution, MSM.


Most glucosamine supplements are manufactured from shell fish, so if you are allergic to shell fish take extreme care in selecting glucosamine supplements. MSM has allergy reactions for some.


Glucosamine used in combination with MSM, chondroitin and Vitamin C has shown promise in treating osteoarthritis. MSM may relieve pain from arthritis and muscle aches and boost the immune system.


Consult with a medical profession before using these supplements if you are taking blood thinners or insulin. If you have kidney or liver problems talk with your doctor before using glucosamine and MSM.

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