Side Effects of Pyridoxine Hydrochloride

Pyridoxine hydrochloride, more commonly known as vitamin B6, is a water-soluble dietary supplement used to treat pyridoxine deficiencies caused by a poor diet, metabolism problems and drug use. Taking the supplement could result in mild side effects, and anyone planning to start a pyridoxine hydrochloride supplement should consult with their health care professional.

Side Effects

It is safe for adults to take up to 200 mg of pyridoxine hydrochloride a day. Taking more than this amount for a prolonged period of time could result in damage to the sensory nerves. The list of possible mild side effects includes numbness, drowsiness, loss of coordination, poor circulation, low serum folic acid levels, photosensitivity and irritation at the injection site if injected. You can also develop a dependency for the supplement. Usually, side effects will go away if you stop taking the supplement, but some symptoms can linger for up to 6 months. If you experience symptoms, notify your health care professional.

At-Risk Populations

Women who are pregnant or nursing should consult a doctor before starting a pyridoxine hydrochloride regiment. Excessive doses of pyridoxine hydrochloride while pregnant can cause a neonatal dependency on the drug. Women who are breastfeeding may experience problems lactating.
Children should not be given more than the daily recommended does unless instructed by a physician since they may be more susceptible to side effects.

Nonlabeled Uses

Pyridoxine hydrochloride has also been known to treat a variety symptoms that are not labeled as uses, including pesticide poisoning, premenstrual symptoms, hyperoxaluria type I, morning sickness, carpal tunnel syndrome, sideroblastic anemia associated with high serum iron, tardive dyskinesia, acne, asthma, alcohol intoxication, hemorrhoids and stimulation of appetite.

Pyridoxine in Food

Pyridoxine can be found in cereals, yeast, meats (especially organs such as liver), fish, soybeans, peanuts and wheat germ. There are also small amounts of pyridoxine in milk and green vegetables.

How It Works

Pyridoxine is converted into phosphates in the red blood cells. Those phosphates act as coenzymes for metabolic functions that include processing proteins, carbohydrates and lipids. The B vitamins are usually absorbed through the intestines, except in people suffering from malabsorption. Pyridoxine is stored in the liver, muscles and brain. Excess amounts are excreted in the urine.

Interactions

The following drugs may interact with pyridoxine hydrochloride, and you should notify your doctor before starting a pyridoxine hydrochloride regimen.
Azathioprine
Chlorambucil
Corticosteroids
Corticotropin
Cyclophosphamide
Cycloserine
Cyclosporine
Ethionamide
Estrogens
Hydralazine
Isoniazid
Levodopa
Mercaptopurine
Oral contraceptives
Penicillamine