Things You'll Need
Bee's nests, also called hives, are usually a nuisance only when they are built into home siding or eaves, or in too-close proximity to human centers of activity. Consider the necessity of killing a bee's nest before doing so, as bees are one of the most important parts of our ecosystem and pollinate most of our food crops, so hives should be left alone if possible. You can also call a professional to determine whether the hive in question can be relocated. All other options out, destroying a bee's nest is not too difficult.
Put on your bee suit. If you don't have one, wear long pants and a long shirt. Tuck your pants into your socks and your sleeves into gloves. Put on the hat and place the netting over the top, tucking the ends into your collar.
Sprinkle borax at the entrance to the hive. The borax is a sure way of killing the entire nest, as bees entering the hive will track it throughout on their legs. If you use only a spray insecticide, the bees at the front of the hive will die, but the rest will likely swarm you—not a good idea.
Wait three or four days. Check the hive daily to see if there is a noticeable decrease in activity. Apply more borax if you think it necessary. After around four days, there should be no activity at the hive.
Clean out the remnants of the hive. If you leave the nest there, it will ferment and attract more insects and rodents.
If you suspect a nest of Africanized or "killer" bees, do not under any circumstances try to approach the nest. These bees are territorial to the extreme and will not tolerate any activity near their nest. They are also very aggressive, and will swarm if you approach the nest. Always call in a professional in case of Africanized bees.
Do not eat the honey from a nest you have killed. It is contaminated.