Although Lexapro has recently been studied for migraine prevention, it is not the first antidepressant drug to be used in this way. Amitriptyline has for years been prescribed as a first-line prophylaxis in migraine treatment. It is a tricyclic antidepressant, which affects the three brain chemicals known to be associated with depression: serotonin, norepinephrine and dopamine.
Until recently, SSRIs (selective serotonin reuptake inhibitors) such as Lexapro had not been considered useful in migraine treatment. However, a study published in the September-October 2009 issue of "Clinical Neuropharmacology" suggests that the SSRI Lexapro and the SRNI (serotonin and norepinephrine reuptake inhibitor) Effexor, also known by the generic name venlafaxine, were also useful in the prevention of migraine.