What Changes Occur as Enzymes Bind?

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A number of different changes occur as an enzymes bind that are definitely worth paying attention to. Find out what changes occur as an enzymes bind with help from an experienced chemistry professional in this free video clip.

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Hi, I'm Dan Weisenberger, and this is what changes occur as enzymes bind. Enzymes are very specialized proteins for the most part that catalyze chemical reactions that occur in the cell in order to generate products that are essential for the survival and growth of the cell. They typically are a part of pathways involving sequential steps by which a compound is taken from one step to another with different enzymes catalyzing several different reactions in order to achieve the final product. Now, enzymes work by coordinating the positioning of the substrates and the co-factors into a small pocket known as the active site in which four of five of the proteins residues coordinate the chemical reaction. And there are two main mechanisms for how this work. One is the lock and key model in which the substrate, shown here, binds perfectly with the structure of the enzyme shown below to make this enzyme substrate complex. When the chemistry occurs, the products are released and the enzyme has the shape that it had initially and is free to do other catalysis. The induced fit model suggests that the substrate and the enzyme do not fit perfectly, but upon the binding of the substrate to the enzyme, the enzyme acquires a structural change that then gives it a structure like the lock and key structure but then it can perform catalysis, and then once the product is released, it goes back to its initial confirmation. Now, one thing to add is that the substrates are also thought to undergo some structural changes during catalysis by which the chemical bonds that are being broken and then reformed with other compounds and ligens undergo strain by the positioning of the enzyme so that it makes it easier for the chemical reaction to occur. I'm Dan Weisenberger, and this is what changes occur as enzymes bind.

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