Toothpaste has a two- to three-year lifespan. "While using expired toothpaste isn't dangerous, the quality can deteriorate," says Dr. Irwin Smigel, cosmetic DDS and founder of Supersmile. "The fluoride may start to dissipate, the paste may become cakey or the toothpaste may not foam as well in the mouth.” Replace toothbrushes once every three months or immediately after any illness.