Antioxidants and anti-inflammatories really are the fountain of youth, says dermatologist Nicholas Perricone, author of "The Perricone Prescription" and "The Wrinkle Cure." You need antioxidants to keep that skin of yours looking beautiful. Anti-inflammatories do just what the name implies: They fight inflammation, inside and out, and also help to keep wrinkles at bay for another day, Perricone says.