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Progestin

    Progestin Editor's Picks

    • How Much Does Ortho Evra Cost?

      Thanks to the number of contraceptive methods available on the market, women can now select from a variety of birth control formats. Indeed, there are so many different products now available that virtually any woman can find her ideal method. Although the birth control pill remains the most commonly used form of birth control, many... more »

    • How to Navigate New Birth Control Options

      Finding the best method of contraception is a very personal choice. Traditional over-the-counter products are still available, but today there are a number of new products that not only prevent conception, but can help you regulate your menstrual cycle, which may also reduce period-related woes, including headaches, cramps, heavy... more »

    • Effectiveness of Birth Control Methods

      The goal of all birth control methods is to prevent an unwanted pregnancy, but some methods are more effective than others. Because cost and the need for a doctor's prescription are factors, some of the most effective methods are not available to everyone who needs them. The Food and Drug Administration (FDA) gathers statistics on the... more »

    • How Effective Is the 72 Hour Pill?

      The 72-hour pill, also known as emergency contraception, the morning-after pill, and E.C., is a strong form of the birth-control pill that is taken after intercourse to remove the uterine lining, decreasing the chances of pregnancy. The pill is usually taken once within 72 hours of having had sexual intercourse (hence the name the... more »

    • About Birth Control Pills & Lack of Vaginal Lubrication

      There can be several side effects to taking contraceptive or birth control pills and one of the most common is vaginal dryness. This means that the vagina just cannot seem to make the same amount of natural lubrication that it used to. This is a normal side effect and nothing to be worried about, but it can make sexual intercourse... more »

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    Progestin

    A progestin is a synthetic progestagen that has progestinic effects similar to progesterone. The two most frequent uses of progestins are for hormonal contraception (either alone or with an estrogen), and to prevent endometrial hyperplasia from unopposed estrogen in hormone replacement therapy. Progestins are also used to treat secondary amenorrhea, dysfunctional uterine bleeding and endometriosis,
    and as palliative treatment of endometrial cancer, renal cell carcinoma, breast cancer, and prostate cancer. High dose megestrol acetate is used to treat anorexia, cachexia and AIDS-related wasting.
    Progesterone (or sometimes the progestin dydrogesterone or 17α-hydroxyprogesterone caproate) is used for luteal support in IVF protocols, questionably for treatment of
    recurrent pregnancy loss, and for prevention of preterm birth in pregnant women with a history of at least one spontaneous preterm birth."Loose 2006">

    History
    The recognition of progesterones ability to suppress ovulation during pregnancy spawned a search for a similar hormone that could bypass the problems associated with administering progesterone (low bioavailability when administered orally and local irritation and pain when continually administered parenterally) and, at the same time, serve the purpose of controlling ovulation. The many synthetic hormones that resulted are known as progestins.

    The first orally active progestin, ethisterone (pregneninolone, 17α-ethynyltestosterone), the 17α-ethynyl analog of testosterone, synthesized in 1938 by Hans Herloff Inhoffen, Willy Logemann, Walter Hohlweg and Arthur Serini at Schering AG in Berlin, was marketed in Germany in 1939 as Proluton C and by Schering in the U.S. in 1945 as Pranone"Inhoffen 1938">"Maisel 1965">"Petrow 1970">"Sneader 2005">"Djerassi 2006">

    A more potent orally active progestin, norethisterone (norethindrone, 19-nor-17α-ethynyltestosterone), the 19-nor analog of ethisterone, synthesized in 1951 by Carl Djera read more at » http://en.wikipedia.org/wiki/Progestin

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