Unless you choose carefully, meat can contribute a significant amount of fat and cholesterol to your diet. When shopping, select lean beef, lamb or pork and trim any visible fat before cooking. Lean options are loin, round, flank, shank cross-cuts and 98 percent fat-free ground beef. Limit your intake of meat to 6 ounces or less per day, recommends the University of Massachusetts Medical School. Tofu and other soy foods are naturally low in fat and cholesterol and make good substitutes.