What Vitamins Are Involved in Glycolysis?


Glycolysis explains the chemical reaction in which glucose is changed into pyruvate. This metabolic process is essential in the formation of adenosine triphosphate molecule (ATP), where the energy is stored in the short term, and NADH, the building blocks for energy. Glycolysis occurs aerobically and anaerobically. Aerobic glycolysis is the primary stage in respiration where glucose converts to carbon dioxide and water. Anaerobic glycolysis breaks down glucose with very small amounts of oxygen in fermentation. Vitamin B-Complex are termed as energy vitamins, because they are directly and indirectly involved in metabolic, energy-producing processes.

Vitamin B1

  • Vitamin B1, or thiamine, gets rid of carbon dioxide from living compounds. Acting as a coenzyme, Vitamin B1 in the form of thiamine pyrophosphate (TPP) instigates the release of carbon dioxide.

Vitamin B2

  • Riboflavin, another component, known as Vitamin B2, combines with FADH2, which assists in glycolysis. Vitamin B2 helps convey electrons in the Krebs cycle, moving them to the electron transport chain.

Vitamin B3

  • Vitamin B3 plays an integral part in glycolytic conversions. Nicotinamide adenine dinucleotide (NADH), an indispensable enzyme to glycolysis, has to be manufactured alongside niacin or Vitamin B3 (one of the complex molecules of Vitamin B). Vitamin B3 is involved in the Krebs cycle (second stage of glycolysis), functioning to transport electrons.

Vitamin B6

  • Vitamin B6 (pyridoxine) is required in glycolysis where stored energy is broken down to more accessible energy forms. A deficiency in Vitamin B6 results in lethargic sensations and extreme fatigue.

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