With a wide variety of pens, a relatively small variation in price can indicate a big change in quality. Finding the right pen for your situation can improve comfort and productivity the workplace or for personal projects at home.
Pilot Easy Touch, Papermate Widemate, Itoya Xenon and Bic Round Stic are all good quality pens for writing. The Pilot Easy Touch, Papermate Widemate and Itoya Xenon have good smoothness of line and comfort. The Bic Round Stic has a strong black line and the clip works particularly well to prevent it from getting lost. The Papermate Widemate is also good for writing on vertical surfaces.
Pilot Precise V5, Staedtler Liquid Point Sanford Uniball Micro, Uniball Vision Elite are rollerball pens. These pens are all particularly good for general writing, but the Staedtler Liquid Point also has a competent clip. The Uniball Vision Elite is made with airplanes in mind -- as a result you won't risk any unsightly leaks when traveling by plane. The Pilot Precise V5 is one of the most commonly used pens on this list and often finds a home with teachers and writers.
Uniball Signo and Pilot P-700 are both good for general writing. The Uniball Signo is retractable and comes with a rubber grip for added comfort. The Pilot P-700, while similar in quality, has a marble barrel that many may find unsightly. Both pens glide smoothly and make for strong, rich lines. The Pilot P-700 also works well for vertical writing.
Specialty pens are much more expensive than the other models but are nonetheless worth mentioning. Popular and well made specialty pens include the Michael's Fatboy Comet, the Limited Edition Walden Woods, and the Celestial Limited Edition - Golden Yellow. The Celestial, perhaps the best looking of the group, is made with 18-karat gold and something of a work of art. Michael's Fatboy Comet is quite popular and designed specifically to prevent calluses, so if you're doing a lot of writing, this may be a good choice. The Walden Woods has a 250 year history and quality to match.