The F350 isn't a truck -- it's a locomotive without rails. While lesser F-150s might do a passable impression of people-movers or off-roaders, big F-Series trucks specialize primarily in eating highway miles in speed and comfort while hauling as much mass as possible. In its 12th iteration, the F-Series got even better at cheating the wind and battering through it with a steeply raked windshield and a number of other little enhancements. Combine that with a couple of massive powerplants, and you could have one serious road train once you take Ford's electronic limiters off.
Top Speed -- Factors
While it is a bit bigger than the F-150, the F-250 and -350 pickups utilize the same aero enhancements and basic shape. As such, the F350 leads its class in slipperiness with an approximate 0.41 to 0.42 drag coefficient, depending on configuration. Standard two-wheel-drive models have about 43 square feet of frontal area. Frontal area is the size of the truck when viewed from the front. This measurement determines how much air the truck has to push out of the way. On the high side, taller and wider four-wheel-drive trucks with dual rear tires have about 52 square feet of frontal area.
Top Speed -- Measurements
Smaller trucks with two-wheel-drive are going to post the highest top speeds, because they have to push less air out of the way. Hypothetically, with the electronic limiter removed, these trucks will hit about 130 to 133 mph with the 316-horse engine, 140 to 143 mph with the 385-horsepower engine and 145 mph with the 400-horsepower engine. The bigger trucks in the lineup would be about 3 to 6 mph slower across the board: about 126 mph, 136 mph and 138 mph with each engine, respectively. If you're looking for more, lowering the standard two-wheel-drive model by three inches will get you an approximate 5 to 6 mph on the top end.