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Equine protozoal myeloencephalitis, or EPM, is one of the most dangerous diseases horses can contract, and is caused by a parasite that attacks the central nervous system. This particular parasite requires two hosts: an intermediate host (such as a skunk or opossum) and a permanent host, which is the horse. Left untreated, this disease can easily kill the permanent host, so it is better to do all you can to prevent EPM in horses.