How to Treat Hypercortisolism

Cushing's Syndrome (also called hypercortisolism) is an endocrine disorder caused by high levels of cortisol in the blood from a variety of causes, including a pituitary adenoma also known as Cushing's disease. This article will explain treatment options for Cushing's disease.

Difficulty: Moderate

Instructions

Things You'll Need:

• Adenoma removal
• Prescription medication
• Complete adrenal removal

1. Know that undergoing surgery is possible If an adrenal adenoma is identified. An hormone-secreting corticotrophic pituitary adenoma removal is recommended after diagnosis. Regardless of the adenoma's location, some patients will require steroid replacement after the operation in the interim as long-term suppression of pituitary ACTH. Be advised of the fact that normal adrenal tissue does not recover immediately. If both adrenal glands are removed, replacement with hydrocortisone is required.

2. Ask about prescription medications. Medications are given to patients that don't want to have surgery or patients who wouldn't be suitable for surgery. Many drugs on the market have been proven to inhibit the overproduction of cortisol such as metyrapone and ketoconazole. Its important to remember that these drugs are very limited in their efficacy.

3. Know that your doctor may recommend your adrenal glands be removed. Doctors will occasionally remove adrenals if no known tumor is found. This process is occasionally performed to eliminate the production of excess cortisol.

Tips & Warnings

• Remember that the majority of cases of Cushing's syndrome are caused by steroid medications. Your healthcare provider may gradually cut back on doses of your prescribed steroid medication to see if this resolves the disorder.

Resources

• Mayo Clinic

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