How to Tranquilize a Cat. Under normal circumstances, you don't need to tranquilize your cat. However, when traveling with a cat it's hard to keep it under control, especially in a car. Constant crying on your cat's part can make a long car trip much longer, so a tranquilized cat is better for you and your cat.
Take your cat to the vet. Have him check your cat out thoroughly so you know that she is fit enough to take the trip you are planning. If you are moving, you have little choice.
Talk to your vet about tranquilizing your cat for the trip. He will usually prescribe a safe medication that you can give your cat. He will also tell you how much to give your cat so it is safe for her. Don't try to give your cat more than she can handle. It is better to get your cat her own prescription, rather than accepting pet tranquilizers from someone who has extra meds left over.
Check with the airlines if you are traveling by plane. You need to know the requirements of your airline for your cat. Some airlines let you take your cat on the plane with you but only if you have a proper cat carrier and it will fit under the seat. Other airlines want to have your cat in the baggage compartment. Check with the airlines you are going on for their requirements.
Give your cat the tranquilizing medication an hour or two before the trip. Again, your vet can tell you exactly when your cat should get the medication. Many cats do not like medicine--kind of like kids--so put the medicine in a pet pocket so you cat will eat it thinking it is a treat. You can buy pet pockets in a pet store--they are treats with a hollow inside.
Carry the tranquilizers with you in case your cat needs another dose before you reach your destination.