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Knowing how to take self employed tax deductions can slash your tax liability with the IRS. There are many things, from computers to health insurance premiums, you can legally deduct to lower your expenses. You can even deduct half of your self-employed income tax, which is the Medicare and Social Security portion of your quarterlies. However, be careful not to take questionable tax deductions, as they may be a red flag for audit. Here's how to take self employed tax deductions.