How to HIV VACCINE RESEARCH SHOULD FOCUS ON PREVENTION, NOT INFECTION

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1. The most practical goal for an HIV vaccine is to prevent HIV transmission rather than infection with the virus, researchers said at the four-day AIDS Vaccine 2007 conference, which began last week in Seattle. Experts believe a vaccine is the only way to eradicate HIV and AIDS because the most common modes of transmission- sexual contact, injection drug use and mother-to-child transmission during childbirth or breast-feeding- are impossible.
2. To eliminate completely, most current HIV vaccine candidates focus on producing cytotoxic CD4+ T cells, which attack HIV-infected cells in the body, according to conference Chair Lawrence Corey, who also is the principal investigator of the HIV Vaccine Trials Network and the head of virology at the University of Washington. Corey added that such vaccines might not prevent an HIV- negative person from progressing to AIDS and prevent transmission to others.
3. Vaccine trial participants are chosen based on health standards for industrialized nations and many people in developing countries are not healthy enough to participate in trials. A coalition of HIV research groups released laboratory guidelines targeted at African populations to enable increased participation in HIV vaccine trials.