What Do Elevated CPK Levels in the Liver Indicate?

Save

Doctors sometimes use the enzyme creatine phosphokinase, found mostly in the heart, brain, and muscles, as an indicator of injury to one or more of these parts of the body.

High CPK levels in the liver imply a disorder called rhabdomyolysis.
High CPK levels in the liver imply a disorder called rhabdomyolysis. (Image: AlexRaths/iStock/Getty Images)

Creatine Phosphokinase

CPK's normal function is the transformation of creatine acid into phosphate, which is a usable source of energy for muscle, heart, and brain cells.

CPK's normal function turns creatine acid into phosphate which we use for energy.
CPK's normal function turns creatine acid into phosphate which we use for energy. (Image: Warren Goldswain/iStock/Getty Images)

Concentration

The normal concentration of CPK in the blood of a healthy adult is 22 to 198 units per liter. An unusually high concentration of CPK may indicate an injury or illness.

The normal concentration of CPK in the blood of a healthy adult is 22 to 198 units/liter.
The normal concentration of CPK in the blood of a healthy adult is 22 to 198 units/liter. (Image: AlexRaths/iStock/Getty Images)

Damage

When an organ or muscle containing CPK is damaged, the bloodstream floods with the "spilled" enzyme. Analyzing CPK levels through a blood test enables doctors to find out exactly what kind of CPK it is, thus revealing where the damage lies.

When an organ or muscles that contains CPK is damaged, the enzyme enters the bloodstream.
When an organ or muscles that contains CPK is damaged, the enzyme enters the bloodstream. (Image: Lisa F. Young/iStock/Getty Images)

Implications

In the liver, the most common explanation for raised CPK is rhabdomyolysis, a common but dangerous skeletal muscle disorder that releases toxins from the muscle cells into the bloodstream.

The most common explanation for raised CPK in the liver is rhabdomyolysis.
The most common explanation for raised CPK in the liver is rhabdomyolysis. (Image: Fuse/Fuse/Getty Images)

Limitations

Fortunately, disease or injury isn't the only explanation for high CPK levels. Vigorous exercise can flood the blood with CPK, as can surgical procedures or even falls. Nevertheless, CPK tests are useful, particularly in differential diagnoses--the systematic elimination of possibilities through a series of tests.

Vigorous exercise can flood the blood with CPK.
Vigorous exercise can flood the blood with CPK. (Image: Maridav/iStock/Getty Images)

Related Searches

References

Promoted By Zergnet

Comments

You May Also Like

Related Searches

Check It Out

This Is the Beauty Routine of a Yelp Sales Manager

M
Is DIY in your DNA? Become part of our maker community.
Submit Your Work!