Side Effects of Similac Premature Infant Formula With Iron


Similac premature infant formula, marketed under the name NeoSure, is formulated with higher protein, calcium and phosphorus than typical formula to assist with weight gain and bone development. It is also fortified with extra iron and essential vitamins.

Common Complaints

  • Parents may notice side effects when introducing an infant to formula and often blame formula for symptoms of colic, gas, constipation, vomiting and fussiness.

Formula Base

  • NeoSure is a milk-based formula based on cows' milk. Soy formulas aren't recommended for premature or low-weight infants due to potentially lessened weight gain.


  • Vomiting or "spit up" is a sign of both overfeeding and formula intolerance, leaving many parents confused. Dr. William Sears, MD states, "Between birth and 6 months of age your baby will need an average of 2 to 2 1/2 oz. of formula per pound per day."


  • The transition from breast milk to formula may result in more frequent vomiting, constipation, fussiness and gas. Infants may need time to adjust to the "heavier" consistency of NeoSure. Contact the pediatrician for signs that the infant is failing to thrive on formula, such as persistent vomiting, weight loss, less frequent urination and prolonged crying.


  • Two studies published in Pediatrics, the official journal of the American Academy of Pediatrics, concluded that no difference in gastrointestinal distress was shown between low-iron and iron-fortified formulas. According to AAP research, mothers commonly conclude that iron causes constipation, due to their experience with prenatal vitamins.

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