Death Due to Statins

Statins are a class of drugs designed to lower levels of LDL ("bad") cholesterol in at-risk individuals. Although these compounds are generally considered to be safe, in rare cases they can trigger life-threatening complications.

  1. The Facts

    • According to the Mayo Clinic, statins are generally well-tolerated, with relatively minor side effects. They achieve their effects by blocking a substance used for cholesterol production.

    Dangerous Side Effects

    • The Mayo Clinic does cite two potentially serious side effects of statin use. In some individuals, statins raise the levels of liver enzymes which, if unaddressed, may lead to permanent liver damage. Statin use may also trigger a life-threatening condition called rhabdomyolysis.

    Rhabdomyolysis

    • Rhabdomyolysis occurs when muscle tissue breaks down and releases a protein called myoglobin. When myoglobin enters the bloodstream in sufficient amounts, it can trigger symptoms including kidney damage, acute kidney failure, coma and death.

    Risk Factors

    • When taken in combination with statins, certain drugs are known to increase the chances of rhabdomyolysis development. These compounds include cyclosporine, niacin, erythromycin, gemfibrozil, verapamil and some antifungals.

    Additional Considerations

    • Taking larger doses of statins may also increase the chances of developing rhabdomyolysis.

Related Searches

References

Resources

You May Also Like

  • How Safe Are Statins?

    Statins are the drugs of choice for treating high cholesterol and are used by millions of patients worldwide. While the accumulated safety...

  • Prevalence of Statin Related Liver Problems

    Statins are the drug of choice for lowering bad cholesterol. Liver problems related to statin use is found in about 1 percent...

  • Are Statins Dangerous?

    Statin drugs such as atorvastatin, simvastatin and lovastatin are prescription drugs that help lower LDL cholesterol levels in patients with high cholesterol....

  • What Drugs Are Statins?

    Statins are one of the most commonly prescribed medications. They are used to lower cholesterol in people with cardiovascular disease. Statins have...

  • The Effect of Statins on the Kidneys

    In some people, high doses of statins may lead to the breakdown of muscle tissue (rhabdomyolysis), which in turn causes the release...

  • Normal Cholesterol Level in Women

    Cholesterol level is an important gauge of heart health. A high cholesterol level is due to poor diet choices, lifestyle and genetics....

  • Dangers of Statins

    You May Also Like. Are Statins Dangerous? Statin drugs such as atorvastatin, simvastatin and lovastatin are prescription drugs that help lower LDL...

  • Statins & Muscle Pain

    Statins are a class of drugs used to lower cholesterol in patients with high cholesterol or other related cardiovascular health issues. They...

  • Rhabdomyolysis Symptoms & Treatments

    Rhabdomyolysis is a breakdown of muscle fiber that leads to myoglobin leaking into the kidneys. It most often occurs after serious injuries...

Related Ads

Watch Video

5 Ways to Keep Your Baby Safe at Home