Geodon & the Effect of Serotonin

Geodon acts as a serotonin antagonist within the brain.

Geodon is the proprietary name for a generic drug known as ziprasidone that the FDA has approved as a treatment for schizophrenia and bipolar disorder. Geodon affects both dopamine and serotonin levels within the brain.

How It Works

Pfizer, the company that manufactures Geodon, acknowledges that the drug's exact mechanism of action in people with both bipolar disorder and schizophrenia is unknown.

Theory

The prescribing information published by Pfizer proposes that Geodon works as an antagonist for specific types of serotonin within the brain.

Effects

People with schizophrenia and bipolar disorder often have high levels of serotonin. As a serotonin antagonist, Geodon blocks serotonin release and also lessens its effect on the brain.

Significance

Serotonin helps to regulate mood, sleep, and learning. As Geodon reduces the impact of excess serotonin on the brain, it typically reduces agitation, improves sleep patterns, and promotes thinking skills in people with mental illness.

Considerations

While Geodon cannot cure the underlying psychiatric disorder, its impact on serotonin levels may help individuals with schizophrenia and bipolar disorder live a more normal life.

References

• Pfizer: Geodon
• eMedTV: How Does Geodon Work?

Resources

• Geodon