Collagen Disorder Information

Collagen disorders can affect almost any body system.

Collagen is a connective tissue found throughout the human body found in bones, tendons, skin and even organs. Collagen disorder is not a condition, but rather a descriptive term applied to several conditions--typically inherited--that affect the formation or health of collagen.

Types

The Arthritis Research Campaign reports that there are four major types of collagen disorder: benign joint hypermobility syndrome, Ehlers-Danlos syndrome, Marfan's Syndrome and osteogenesis imperfecta.

Causes

Collagen disorders are typically the result of inherited genetic abnormalities. However, the genetic abnormalities are condition-specific.

Symptoms

The symptoms of collagen disorders can vary widely by condition and severity. They can include skin abnormalities, hypermobility in the joints, scoliosis, cardiovascular problems, bone fragility and vision problems.

Treatments

Treatments are also variable depending on the specific condition but may include corrective surgical interventions for bone or cardiovascular abnormalities, medications, physical therapy and braces.

Medical Limitation

There are no cures available for collagen disorders; treatment modalities focus on management of symptoms. Due to the possibility of lethal versions of the conditions manifesting, those with collagen disorders may be discouraged from having children.

References

• Rheumatic Diseases; Heritable Collagen Disorders -- Arthritis Research Campaign
• Collagen; The Fibrous Proteins of the Matrix