Can You Take Tylenol Sinus With Mucinex?


Cold and flu season has reared its ugly head, and you want to take anything you can to feel better. Mixing drugs--prescription or over-the-counter--is tempting but not always a good idea.

Tylenol Sinus

  • The active ingredients in Tylenol Sinus are acetaminophen, guaifenesin and phenylephrine. Acetaminophen treats pain, guaifenesin is an expectorant, and phenylephrine is a decongestant.


  • The active ingredient in Mucinex is guaifenesin, an expectorant.

More is Not Always Better

  • There really is no need to take Tylenol Sinus and Mucinex together--Tylenol Sinus includes the active ingredient of Mucinex.

Alternate Doses

  • If you want to take Tylenol Sinus and Mucinex, alternate doses. Take Tylenol Sinus as directed, and, rather than taking the next dose, switch to Mucinex for that round and repeat. By following this routine, you will gain the benefits of both medications without increasing your risk of overdose.

Symptoms of Overdose

  • If you experience flushing, diarrhea, confusion, numbness of your fingers or toes, vomiting, nausea or hallucinations, stop taking the drugs immediately, and consult your doctor.

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