Epithelialization is the natural act of healing dermal and epidermal tissue in which epithelium grows over a wound. Epithelium is a membranous tissue made up of one or more layers of cells that contains very little intercellular substance.
Epithelialization is a complex process of tissue repair consisting of three overlapping phases.
When the skin is wounded, blood comes into contact with collagen that triggers blood platelets to secrete inflammatory factors. Homeostasis (stopping blood loss) takes place through the clotting cascade. Plasma proteins are released to attract cells that phagocytise (ingest foreign particles). This cellular migration to the wound area is the first line of defense against debris, bacteria, and damaged tissue.
Two to five days after the onset of the wound, patent cells begin to sprout cells (angioblasts) into the wound, forming new capillary loops. Type III collagen is produced forming "granulation tissue."
Remodeling begins when special cells (myofibroblasts) appear. Their muscle-like contracting proteins act on the wound as a whole, shrinking the wound.
Wound-healing disorders interfere with natural epithelialization. Chronic wounds can be recognized by a loss of skin around the wound. Such wounds can result in serious medical complications and require immediate and intense medical intervention.
- "Management of Common Musculoskeletal Disorders;" Darlene Hertling; 2005
- Columbia University Medical Center: Wound Healing
- Photo Credit Image by Flickr.com, courtesy of wickedchimp
What is Serous Drainage?
Serous drainage is normal drainage from a healing wound or incision. Knowing what to expect during the healing process, which begins immediately,...
Cicatrix for Acne
Acne is a problematic condition for many people. Aside from its prevalence, it also has damaging effects to the skin, causing scars...
What Is Granulation in a Wound?
A deep wound can necessitate a visit to a physician and several months of healing time. During this time, the wound goes...
Infected Toe Treatment
Infected toes can be caused by a variety of triggers: fungi, open cuts or wounds on the toe, ingrown toenails, and shoes...