Early Signs & Symptoms of Multiple Myeloma


Multiple myeloma is a bone-marrow cancer occurring when the body makes too many abnormal plasma cells. The disease is more common in those over 60 and in African-Americans. There is no cure for multiple myeloma, but symptoms can be treated to allow patients to live more normally.

Bone Pain

  • One of the main early symptoms of multiple myeloma is bone pain. This will be felt mainly in the skull, ribs, back and pelvis.

Abnormal Proteins

  • Abnormal proteins are an early symptom of multiple myeloma. These proteins are called monoclonal proteins and are found in blood or urine.


  • Another early sign of multiple myeloma is having high levels of calcium in your blood. This happens when calcium from cancerous bones dissolves into blood.

Other Symptoms

  • Other symptoms of multiple myeloma include constipation, loss of appetite, nausea, excessive urination and thirst, weight loss, confusion, anemia, fatigue, repeated infections such as sinusitis, and leg weakness or numbness.


  • Standard treatment of multiple myeloma includes medicines that kill cancer cells, chemotherapy, radiation, oral corticosteroids and stem-cell transplant.

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