- Long-term use of naproxen increases the risk of heart attack for even healthy patients, according to the Mayo Clinic.
- Those with existing heart disease should consider not taking naproxen because of the increased heart attack risk, according to the Mayo Clinic.
- Side effects associated with treatment that might indicate possible heart problems include chest pain, tightness in the chest and difficulty breathing, according to the Mayo Clinic.
- Another NSAID, Vioxx, was voluntarily recalled by its manufacturer in 2004 because of studies proving the medication caused heart attack and stroke deaths, according to the U.S. Food and Drug Administration.
- The FDA has stated that Vioxx and naproxen are indeed chemically similar, but that the existing risk for heart attack and stroke associated with naproxen is not nearly as high as the risk associated with Vioxx.








