- Causes of weight gain in people with clinical depression include comfort eating, reduction of exercise because of fatigue and chronic pain, and side effects from antidepressants.
- According to Psychology Today, antidepressants commonly cause people to gain weight, especially Lexapro (escitalpram), Paxil (paroxetine) and Marplan (isocarboxazid).
- The National Alliance on Mental Health states that many antidepressants can cause both an increase in appetite and drowsiness. This combination may make a person eat more calories but burn fewer calories.
- According to the Mayo Clinic, there is no way of testing if an antidepressant will give a particular person extra pounds. People on antidepressants need to monitor their weight and begin dieting and exercising throughout treatment.
- The Family Intervention Guide to Mental Illness by Bodie Morey and Kim T. Muesser states that the benefits of antidepressants outweigh the risks.










