Signs of Stomach Damage Due to Ibuprofen
Ibuprofen is an over-the-counter drug used to relieve mild to moderate pain and reduce inflammation, stiffness and fever. Available in brands such as Advil and Motrin, ibuprofen is categorized as a non-steroidal anti-inflammatory drug (NSAID). Many side effects are associated with these medications, including stomach and intestinal damage.
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Function
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Ibuprofen inhibits the activity of cyclooxygenase (COX) enzymes involved in the synthesis of prostaglandins. Prostaglandins are responsible for inflammatory and pain reactions to injury or disease. They also protect against the development of stomach ulcers.
Common Side Effects
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Common gastrointestinal effects linked to ibuprofen use include stomach pain, constipation or diarrhea, gas, heartburn, indigestion and nausea.
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Warning
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Ibuprofen can increase the risk of severe effects on the stomach or intestines, including bleeding, ulcers or perforations. These conditions can be life-threatening and can occur with no early gradual symptoms.
Gastrointestinal Signs
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Signs of stomach or intestinal damage due to ibuprofen use include dizziness from internal bleeding, tar-like or bloody stools, blood in the urine, or vomiting up blood or material that looks like coffee grounds. Abdominal pain may occur, but not always.
Contraindications
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People with a history of gastrointestinal ulcers or bleeding should not use ibuprofen. The risk of ulcers increases when aspirin and ibuprofen are taken together.
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