Harmful Side Effects of Voltaren Gel


Voltaren Gel is a prescription topical gel that contains diclofenac sodium. Despite its effectiveness at alleviating the discomfort associated with osteoarthritis, Voltaren Gel poses a risk for harmful side effects in some patients.

Types of Skin Side Effects

Voltaren Gel has the potential to cause serious skin reactions, including vesicles or a rash caused by liquid being trapped in the cells beneath your skin. Another possible type of reaction are papules or solid nodules.


Despite the fact that they are the most common severe side effects of Voltaren Gel, papules and vesicles occur in less than 1 percent of patients, according to RxList.

Drug Interactions

When combined with blood thinners like warfarin, Voltaren Gel poses a risk for sudden, severe bleeding in your digestive system. Voltaren Gel can also cause toxic effects when used with the arthritis drug methotrexate, the psychiatric drug lithium or diuretics used to treat hypertension.


There is a slight risk of heart attack or stroke associated with use of Voltaren Gel. The medication also has the potential to damage your liver or to cause ulceration in your stomach or intestines.


Voltaren Gel poses a risk for fetal abnormalities when taken during the third trimester of pregnancy, according to RxList. If you have a history of anemia, asthma, bleeding disorders, blood clots, edema, heart attack, stroke, cardiovascular disease, hypertension, aspirin sensitivity or kidney or liver disease, it may not be safe for you to use Voltaren Gel, cautions the Mayo Clinic.

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