- There are two types of Synvisc knee treatments: Synvisc and Synvisc-One. According to synviscone.com, the only difference between the two is that Synvisc-One requires only a single injection, while regular Synvisc requires three (Reference 1).
- Synvisc injections are performed at your doctor's office in a matter of minutes. Synviscone.com advises that you not perform any strenuous activities for 48 hours after the procedure (Reference 1).
- Synviscone.com states that it may be as much as one month before Synvisc injections take effect. If your osteoarthritis knee symptoms return after this time, call your doctor (Reference 1).
- Synvisc knee injections may be very painful (Reference 2). Other side effects may include rash, swelling, stiffness and fluid buildup near the injection site (Reference 1).
- According to the Johns Hopkins Arthritis Center, there are methods the physician can utilize to reduce the pain associated with Synvisc knee injections. First, your doctor may spray a numbing topical anesthetic on your knee prior to the injection. Another method is to inject an anesthetic into your knee before administering Synvisc (Reference 2).











