Advil PM Side Effects


Advil PM is a medication containing ibuprofen and diphenhydramine (Benadryl) that is used as a sleep aid and pain reliever. Side effects include dry mouth, headache, nausea, diarrhea, abdominal pain, rapid heart rate, urinary retention, itching, headache and bruising.

Time Frame

  • If the individual experiences side effects, he should notify his doctor immediately, because even minor side effects can rapidly turn serious if not treated quickly. In order to minimize the risk of side effects, Advil PM should not be taken more frequently than every 4 hours.


  • There is no effective way to prevent Advil PM side effects; however, the risk can be reduced if the recommended dosage is followed and if the individual does not take it more frequently than the directions advise. With most medications, it is important to drink plenty of water to keep hydrated and replace fluids in the event of nausea, vomiting or diarrhea, which can be a dangerous side effect.


  • A common misconception about Advil PM is that it is without side effects. This is thought to be true because it is an over-the-counter medication. Many individuals believe that the active ingredients are harmless; however, ibuprofen can cause serious side effects such as bleeding, and diphenhydramine can cause heart irregularities.


  • Some people are allergic to Advil PM and can experience a severe reaction such as swelling of the lips and throat. This is a life threatening situation, and emergency medical intervention must be sought immediately.


  • Since side effects of Advil PM can include bleeding tendencies, aspirin should never be taken with it. Aspirin is a powerful anticoagulant (blood thinner) and can cause serious bleeding.

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