Progesterone Suppository Side Effects


Progesterone suppositories (Endometrin) are a prescription cream capsule for insertion into the vagina used during fertility treatments as well as to induce menstruation or to prevent the overgrowth of uterine lining after menopause. Despite their effectiveness, progesterone suppositories pose some risks for side effects.

Types of Common Side Effects

The most common side effects of progesterone suppositories include abdominal pain, nausea, bloating, constipation, vomiting, fatigue, urinary tract infections, headaches, uterine contractions, headaches, breast tenderness, mood swings and vaginal bleeding.


The most common side effects of progesterone suppositories occur in 2 to 12 percent of patients, according to RxList.

Drug Interactions

Other types of vaginal suppositories, such as those used to treat yeast infections, may interfere with the effects of progesterone suppositories or cause an increased incidence in side effects, according to RxList.


Use of progesterone suppositories poses a risk for heart attack, blood clots and strokes. If you develop any signs of these life-threatening cardiovascular condition like shortness of breath, numbness or chest pain, seek emergency medical attention.


Because the use of the suppositories poses a risk for birth defects, avoid using progesterone during pregnancy. If you have a history of blood clots, miscarriages, ectopic pregnancy, liver disease or breast cancer, your doctor is not likely to prescribe progesterone suppositories due to their side effects.

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