5-Hour Energy Side Effects


The two ounces of liquid inside a 5-Hour Energy shot contain numerous ingredients, including vitamins, amino acids and significant quantities of caffeine. Side effects differ depending on the specific shot. Extra Strength 5-Hour Energy contains stronger doses than a Decaf 5-Hour Energy shot does.


As an energy drink, 5-Hour Energy delivers. The original energy blend contains as much caffeine as a small cup of coffee.

Skin Reaction

The presence of niacin, also known as vitamin B3, can cause a skin reaction, called a niacin flush, that causes the skin to become red and itchy. The effects should not last more than 30 minutes.

B6 Overdose

Drinking five bottles of the original 5-Hour Energy blend can cause a Vitamin B6 overdose that leads to nerve toxicity or paralysis.

Caffeine Overdose

Ingesting too much caffeine in a short period of time can cause involuntary shaking, nausea, vomiting, irregular heart beat, panic attacks and disorientation. Gastro-intestinal pain, dehydration, diarrhea and headaches are also possible.

Risk Groups

There are many groups of people who should consult their doctor before using 5-Hour Energy. These include anyone taking prescriptions and anyone who has been directed to avoid stimulants. Pregnant women, young children, and people with phenylketonuria (PKU) should avoid it altogether.

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