Lisonopril Side Effects

According to PharmacyOneSource, a medication management system used by hospitals, Lisinopril (brand names Prinivil, Zestril) is a medication approved by the Food and Drug Administration for congestive heart failure, diabetic neuropathy, hypertension and myocardial infarction.

  1. Mode of Action

    • Lisinopril is an angiotensin converting enzyme (ACE) inhibitor and works by decreasing peripheral vascular resistance and blood pressure.

    Cardiovascular Side Effects

    • Patients have reported cardiovascular side effects such as low blood pressure and angioneurotic edema (painful swelling of the skin), angina pectoris, orthostatic hypotension and palpitations.

    Nervous System

    • Nervous system side effects are the most common in patients taking Lisinopril and include dizziness, headache and tingling of extremities.

    Gastrointestinal

    • Diarrhea, nausea, vomiting and less frequently altered taste, pancreatitis and constipation have been reported.

    Warnings

    • In October 2005, the FDA issued a black-box warning regarding the potential for angioedema (swelling of the tongue, lips and larynx) in patients taking Lisinopril.

      In 2006 the FDA issued a drug alert for all angiotensin converting enzyme (ACE) inhibitors and the increased risk of fetuses developing congenital abnormalities when mothers take these drugs while pregnant.

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