What to Do for Cymbalta Withdrawals


Cymbalta is the brand name for the medication duloxetine hydrochloride, prescribed to treat depression, generalized anxiety disorder, neuropathic pain and fibromyalgia. Cymbalta is classified as a serotonin-norepinephrine reuptake inhibitor (SNRI). Most people who stop taking Cymbalta have only mild or moderate withdrawal symptoms.

Discontinuation Syndrome

  • SNRIs are associated with varying degrees of withdrawal symptoms when a patient suddenly discontinues the drug. These symptoms are sometimes referred to as anti-depressant discontinuation syndrome.


  • In clinical studies with Cymbalta, as detailed by eMedTV, nearly half the people who suddenly stopped taking Cymbalta experienced some type of symptoms. The most common effects were dizziness, headaches, irritability, nausea, vomiting, nightmares and tingling or burning skin sensations.

Motion Sickness Medication

  • People dealing with nausea, irritability and sleep disturbances may find some relief by taking the motion sickness medication dimenhydrinate, available in generic form and under brands such as Dramamine.

Antacids and Analgesics

  • Over-the-counter antacids also can help relieve nausea and upset stomach symptoms. Pain relievers such as ibuprofen, aspirin and acetaminophen can relieve headaches associated with Cymbalta withdrawal.

Gradual Discontinuation

  • If symptoms are severe, the doctor may recommend taking Cymbalta again and discontinuing it slowly over at least two weeks.


  • People experiencing Cymbalta withdrawal can benefit from seeking support from family, friends and their health care provider. Additionally, online support groups are available to help. See Resources below for a link to a community forum.


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