Provigil for MS Side Effects

Provigil is a brand name for the stimulant modafinil, usually prescribed for improving wakefulness in people with obstructive sleep apnea, narcolepsy and shift work sleep disorder. Physicians also prescribe Provigil to treat fatigue due to multiple sclerosis and chronic fatigue syndrome. Numerous side effects are possible.

Most Common Effect

In clinical studies with Provigil, the most common side effect was headaches, experienced by up to 34 percent of participants.

Other Side Effects

Additional Provigil side effects experienced by over 5 percent of study participants included back pain, diarrhea, nausea, nervousness and a runny or stuffy nose.

Less Common Effects

Between 1 to 5 percent of people experienced other side effects. These included cold sores, constipation, drowsiness, dry mouth, flu-like symptoms, flushing or hot flashes, loss of appetite, neck stiffness, sore throat and many others.

MS Study

In a 2000 study conducted by an associate professor of neurology at Ohio State University, MS patients with severe fatigue had success with the 200 milligram dose of Provigil, but the 400 mg dose caused unfavorable side effects, including headaches, nervousness and loss of physical strength.

Warning

Provigil use is linked to Stevens-Johnson syndrome, a rare but dangerous side effect. This disorder begins as a rash, but can progress to blistering and peeling of skin that becomes life threatening.

References

• Provigil side effects
• Multiple sclerosis and Provigil study

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