Adverse Effects of Estrogen Cream

Estrogen cream is a topical treatment prescribed to alleviate one of the unpleasant effects of menopause: a very dry vagina. However, the body can absorb a small amount of estrogen from this cream, which can cause some adverse effects if used for a prolonged time frame.

Common Effects

The most common side effects are breakthrough bleeding or spotting, and abnormally long periods.

Other Adverse Effects

Other somewhat common side effects can include vaginitis, breast tenderness or pain, and an increased or reduced interest in sex.

Less Likely Effects

Dizziness, lightheadedness, headache, indigestion, nausea and bloating also can occur when using estrogen cream.

Drug Interactions

Estrogen absorbed from the cream can interact with numerous other medications, including cyclosporine, dantrolene, anti-coagulants, barbiturates, antidepressants and other drugs.

Warning

Estrogen, though rarely, can cause cardiovascular problems. Symptoms should be reported to a physician immediately; they include chest pain, shortness of breath, weakness, slurred speech, sudden severe headache, blurred vision, or swelling of hands, feet or legs.