The Effects of Depakote & Alcohol

Depakote is the brand name of the medication divalproex sodium, prescribed to treat seizure disorders, the manic phase of bipolar disorder, and for the prevention of migraine headaches. Manufactured by Abbott Laboratories, it shows promise for treating alcohol withdrawal.

  1. Depakote and Alcohol

    • People taking Depakote should be cautious about drinking alcohol, because the medication depresses central nervous system activity and can increase the effects of alcohol.

    Liver Problems

    • Additionally, Depakote has been associated in rare cases with liver failure, and people who drink are more at risk for liver problems. Symptoms of liver damage include nausea and vomiting, dark urine and jaundice.

    Milwaukee Study

    • A study at Aurora Sinai Medical Center in Milwaukee found that Depakote may be a safe and effective treatment for alcohol withdrawal, including outpatient detoxification.

    Maryland Study

    • Research from the University of Maryland in Baltimore found that over half of patients treated with Depakote in one study reduced their substance abuse behavior.

    Washington Study

    • Researchers at the University of Washington have concluded that Depakote significantly and positively influences the course of alcohol withdrawal and reduces the need for treatment with benzodiazepines.

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