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Does Stopping Smoking Affect Medicine Absorption?

Many doctors request patients stop smoking when prescribing medicine, insinuating that smoking affects the function or absorption of the medicine.

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    1. Research Findings on Smoking's Relation to Medicine Absorption

      • There has been research as early as the 1970s suggesting cigarette smoking increases drug metabolism, rendering certain drugs less effective in heavy cigarette smokers.

      Smoking Reduces Potency of Psychological Drugs

      • Cigarette smoking decreases the effectiveness of antidepressants, anti-anxiety drugs, and psycho-relaxants.

      Specific Drugs Smoking Reduces Potency Of

      • Smoking reduces the effectiveness of benzodiazepines, propoxyphene (Darvon), pentazocine (Talwin), diazepam (Valium) and chlordiazepoxide (Librium).
        Cigarette smoking has no effect on phenobarbital effectiveness.

      How Does Smoking Affect Drug Metabolism?

      • The liver of heavy smokers produce enzymes that metabolize some types of drugs faster than in non-smoking individuals. Because of the much shorter duration of the medicine's presence in the body, the medicinal effects are diminished.

      Stopping Smoking Will Affect Medicine Absorption

      • If you are taking any of the medicines listed above, stopping smoking will improve absorption.

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