Water Pill Side Effects


Water pills, also called diuretics, help your body get rid of salt and water from the blood and are used to treat chronic medical conditions such as high blood pressure, glaucoma and edema. The side effects of water pills depend on the type being used and the presence of other medical conditions such as kidney and heart disease. Although most of the side effects of water pills are mild and temporary, some may require medical evaluation to prevent complications.

Increased Urination

  • According to the Mayo Clinic, water pills may increase the frequency of urination.

Muscle Cramps

  • Water pills such as thiazide are diuretics that reduce the amount of potassium in the blood. Their use may result in muscle cramps, especially in the calf of the leg.

Blood Sugar

  • Increased blood sugar may be a result of water pills, because the amount of sugar in the blood becomes concentrated from the loss of water.


  • If a person with normal blood pressure levels takes water pills, her blood pressure may drop, resulting in dizziness or fainting.

Stomach Pain

  • Water pills may cause digestive side effects such as gas, stomach pains, nausea or vomiting.


  • People taking water pills may experience an allergic reaction to active ingredients such as sulfonylureas, which may result in a skin rash.


  • Side effects including jaundice, dark urine, light stools, fever, muscle weakness or inability to urinate may indicate a serious medical condition and require urgent medical treatment.

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