Nimesulide Side Effects


Nimesulide is a medication that is in a class of drugs called "non-steroidal anti-inflammatory drugs." It is an analgesic and antipyretic that is used to treat mild to moderate pain as well as reduce fever and inflammation. Nimesulide is available in several forms including tablets, water-soluble powders, suppositories and topical gels. A doctor should be consulted before taking Nimesulide as it has been linked to possible side effects.

Side Effects

  • As with any medication, there are certain negative side effects that may be experienced while taking Nimesulide. Some common side effects linked with Nimesulide use are nausea, vomiting, diarrhea, pruritis, skin rashes, headaches and dizziness. Some serious side effects when used in newborns are renal failure and hepatic failure. A doctor should be consulted if any adverse side effects are experienced.


  • Nimesulide is known as both an analgesic and an antipyretic. defines an analgesic as "A drug or medicine given to reduce pain without resulting in loss of consciousness. Analgesics are sometimes referred to as painkiller medications." This website defines an antipyretic as "Something that reduces fever or quells it."


  • Elderly people and individuals with renal impairment should exercise caution while taking Nimesulide. This medication is known to decrease the effects of diuretics and Beta-blockers. Like most non-steroidal anti-inflammatory drugs, Nimesulide is hepatotoxic, which means that it can be damaging to the liver.


  • According to, "It [Nimesulide] did not achieve Food and Drug Administration (FDA) approval in the USA, and is banned in many countries due to cases of jaundice and hepatitis induced by its use. Italy was the first country to allow the drug in 1985. The European Medicine Evaluation Agency has prohibited the use of Nimesulide for children under the age of 12. Currently, Nimesulide is still available in many countries."


  • The typical tablet dose for a healthy adult is 100 mg to 200 mg, taken twice daily. Individuals should never take more than the recommended dose of this medication as it may lead to an increased likelihood of experiencing adverse side effects.

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  • Photo Credit Image by, courtesy of Michael Chen
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