Uric Acid & Cardiovascular Disease

According to the Mayo Clinic, cardiovascular disease is the top cause of death in the United States. There are several things that point to increase risk of cardiovascular disease such as obesity and smoking. A study conducted by Verdecchia et al. found that high levels of serum uric acid have a correlation with cardiovascular disease as well.

  1. Cardiovascular Disease

    • Cardiovascular disease, also known as CVD or heart disease, covers a variety of conditions which affect the heart and blood vessels. This includes coronary artery disease, heart arrhythmias, and congenital heart defects. Because of the number of poor lifestyle choices (smoking, drinking alcohol, and overeating) that contribute to the cause of cardiovascular disease, many efforts exist to inform individuals about the risks of their actions. The studies on uric acid levels and cardiovascular disease are another piece to understanding the impact of diet on heart disease.

    Uric Acid

    • Uric acid is a byproduct of the metabolism of purines. According to Verdecchia et al., uric acid has antioxidant capabilities; however, it may be toxic in high levels and can cause damage to the tissue. Excess uric acid is normally excreted through urine. The existence of high uric acid levels in individuals with cardiovascular disease is unclear. The PIUMA Study is unsure of the role that high uric levels play in cardiovascular disease, but there is a strong correlation between them suggesting that their relation requires further study.

    Controversy

    • Several studies found correlations between serum uric acid levels and the occurrence of cardiovascular disease. However, these initial studies were questioned because the correlation was insignificant due to other risk factors present in the participants. The current study aimed to dispel those claims by controlling other risk factors. Once controlled, Verdecchia et al. found that the correlation was significant, which strengthened the correlation between uric acid and cardiovascular disease.

    Study's Procedure

    • The Verdecchia et al. study, or the PIUMA Study, followed more than 1,500 people for approximately 10 years. In the initial portion of the study, each patient's resting blood pressure (BP) was measured and recorded by a doctor. The patients' ambulatory BP was also measured. This was done systematically over a 24-hour period with a device the participant wore. Participants were later followed with their doctor's office reporting their health status, including any cardiovascular events (stroke, heart attack, etc.). Uric acid levels were noted as well.

    Results

    • According to Verdecchia et al., the results of the PIUMA study showed that participants with the highest level of uric acid had more cardiovascular events than patients with lower levels of uric acid. Not only were they more at risk for a cardiovascular event but they also were more at risk for fatal cardiovascular risks and mortality in general. Verdecchia et al. concluded that if hypertension is untreated in an individual, high uric acid levels are indicative of cardiovascular disease.

Related Searches

References

  • Hypertension; Relation Between Serum Uric Acid and Risk of Cardiovascular Disease in Essential Hypertension; Paolo Verdecchia, Giuseppe Schillaci, GianPaolo Reboldi, Fausto Santeusanio, Carlo Porcellati, Paolo Brunetti; 2000
  • Mayo Clinic

You May Also Like

  • Uric Acid & Heart Disease

    According to an article in the Journal of the American Medical Association, a chemical called uric acid that is found within our...

  • Uric Acid Disease

    Uric acid is a normal chemical found in the blood. It occurs when the body digests certain foods or drugs that contain...

  • Uric Acid Problems

    Uric acid is naturally present in the body and is a byproduct of certain foods. However, when too much uric acid is...

  • Uric Acid Metabolism

    The Mayo Clinic describes uric acid as a byproduct of purines, a natural substance in foods. The uric acid then finds its...

  • Precautions to Lower Uric Acid

    Uric acid is a normal component of the blood. It is created by the body naturally when certain foods and drugs are...

  • How to Reduce Uric Acid With Vitamins

    Excessive uric acid in a person's body can lead to uric acid crystals forming in the joints and in tissue surrounding the...

  • How to Lower Uric Acid to Prevent Gout

    A common form of arthritis called gout is caused by high levels of uric acid in the blood stream. To prevent gout,...

  • Symptoms Due to Increased Uric Acid

    Uric acid levels can become elevated under certain conditions, and those who have high levels of uric acid in their blood (known...

  • Foods to Fight Uric Acid in Blood

    Uric acid in your blood comes from the breakdown of purine, a substance found in many foods. A high concentration of uric...

  • Possible Causes of Low Uric Acid Levels

    Uric acid (urate) is an organic compound that is a factor in purine metabolism, which is an important part of RNA and...

  • Signs & Symptoms of Cardio Vascular Disease

    Cardiovascular disease, also known as heart disease, is the top reason for death in both women and men worldwide, according to the...

  • Foods to Avoid for High Uric Acid Levels

    Uric acid is a waste substance excreted by the kidneys. Hyperuricemia is the medical term for elevated uric acid. This imbalance results...

  • What Are Normal Uric Acid Levels?

    Uric acid is a chemical created by the breakdown of purines, organic compounds that are found in wine, beer, dried beans, anchovies,...

  • Foods That Lower Uric Acid Levels

    Purines are found in body tissues, some foods and beverages. Uric acid is a chemical created when the body breaks down purines,...

  • How to Reduce Uric Acid and Relieve Gout

    Do you need to know how to reduce uric acid and relieve gout? Gout is a painful form of arthritis located in...

  • How to Reduce Uric Acid

    Uric acid is a waste product that the body produces after it breaks down purines in the body. After the breakdown occurs,...

  • Information on Uric Acid Kidney Stones

    A kidney stone is a buildup of minerals and crystals that have separated from the urine within the urinary tract. Uric acid...

  • Foods High in Uric Acid

    Foods that are high in uric acid include coffee, alcohol, meats and dairy, and excess of these foods can cause stress on...

  • What Are the Causes of Uric Acid?

    Uric acid is an oxidation product of purine metabolism, is usually converted to urea by our kidneys, and is finally secreted from...

Related Ads

Watch Video

5 Ways to Keep Your Baby Safe at Home