Simplicef for Cats


Simplicef is the brand name for Cefpodoxime proxetil, an oral medication produced by Pfizer used to combat bacteria-based infections in both cats and dogs. While this product is FDA approved only for skin infections in dogs, it is legal and common practice for veterinarians to prescribe Simplicef for cats as well.

How Simplicef Works

Providing the body protection against bacteria, Simplicef destroys existing bacteria and prevents new bacteria from forming. When bacteria is present in the body, it will try to form a protective cell wall making it more difficult to eradicate. Simplicef prevents this wall from being formed, creating instability for the bacteria that results in its death.


Simplicef is used to treat a wide variety of infections caused by bacteria, including but not limited to pneumonia and bladder, ear, wound and skin infections. Numerous bacterial strains such as Staphylococcus aureus, Staphylococcus intermedius and Pasteurella multocida can be treated with Simplicef. While Simplicef is effective against bacteria, it is ineffective against parasite- or viral-based infections


Because Simplicef is not FDA approved or regulated for cats, a veterinarian will determine dosage based on the size of cat and the illness being treated. A cat's symptoms may subside before the entire prescription has been taken. Regardless, complete the dosage as prescribed by the vet.

Side Effects

As with any new drug, a pet should be closely watched for allergic reaction such as hives, trouble breathing, swelling, nausea, vomiting, diarrhea or any unusual bleeding. Common side effects like diarrhea, yeast infection or moderate nausea may also occur. If these symptoms are mild, continue dosage instructions and contact your vet. In the case of more severe symptoms, such as bloody diarrhea or severe vomiting, discontinue use and contact your vet immediately. Before beginning Simplicef, notify your veterinarian of any medications, vitamins and herbal products that you give your pet to avoid possible drug interaction.


Simplicef is in the cephalosporin class of antibiotics, so notify the vet of any previous allergic reactions to penicillin or another cephalosporin before giving your cat Simplicef. Likewise, tell your veterinarian if you cat has stomach, intestinal or kidney disease, or if your cat is pregnant or lactating. Talk to your veterinarian or pharmacist before giving any prescription or over-the-counter medicines, including vitamins, minerals and herbal products.

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