Risks of Using Tylenol PM
Tylenol PM is a combination of diphenhydramine HCl and acetaminophen. Diphenhydramine is sold under the brand name Benadryl and acetaminophen is the active ingredient in regular and Extra Strength Tylenol. Together, they provide pain relief and a drowsy effect to help promote restful sleep. However, there are some risks to be aware of when using Tylenol PM.
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Liver Problems
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The top concern when taking any Tylenol product is the risk of liver damage that has been associated with acetaminophen. This is not usually a problem with occasional use of Tylenol PM. According to the Food and Drug Administration, liver damage from acetaminophen occurs with long-term use or use in excess (more than the recommended 4,000 mg in a day, or a dose of more than 1,000 at a time). To avoid this health risk, take Tylenol PM as directed for no longer than two consecutive weeks.
Diphenhydramine Side Effects
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Diphenhydramine is frequently used as an allergy medication and is generally well-tolerated. Possible side effects include gastrointestinal discomfort; drying of the mouth, nose or eyes; low blood pressure; increased heart rate or palpitations; and vision problems. These side effects often disappear when your body adjusts to Tylenol PM. There is more of a risk with diphenhydramine use in those with asthma, glaucoma, enlarged prostate, hyperthyroidism and cardiovascular disease.
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Sedation
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Tylenol PM is produced as a sleep aid because diphenhydramine can cause dizziness and drowsiness. Since this medication has a sedating effect for most people, it should not be taken during waking hours by those who may drive or operate heavy machinery. Tylenol PM may also impair judgment or make it difficult to concentrate.
Drug Interaction
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There are certain drugs that should not be taken with Tylenol PM because there is a risk of interaction. Warfarin, a blood thinner, can have dangerous consequences when taken with Tylenol PM. You should not take tranquilizers, sedatives or muscle relaxers with Tylenol PM. Alcoholic drinks and additional products containing acetaminophen (including prescriptions labeled APAP) will increase the likelihood of liver toxicity when combined with Tylenol PM.
Considerations
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Discuss use of Tylenol PM with your doctor. Tylenol PM is not recommended for pregnant women or nursing mothers. It can be a safe aid to restful sleep for those suffering from pain or headaches, but only a health care provider can weigh the risk for an individual patient and decide if Tylenol PM is a safe alternative.
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