Propalin Syrup Side Effects


If your spayed female dog leaks urine, your vet might prescribe Propalin syrup to ease the problem. Propalin contains phenylpropanolamine, which improves canine urethral tone. Some dogs respond very well to this therapy, with the urine leakage virtually stopping. Other dogs may leak less often and in smaller amounts, but there is no effect in some canines receiving this medication. It's very much an individual response.

Administering the Syrup

Your vet will calculate the correct dosage of Propalin syrup for your dog based on her body weight. Do not exceed the recommended dosage -- that's when side effects are more likely to occur. You can give the medication directly to your dog or add it to her food.

Vomiting, Seizures or Other Side Effects

Propalin syrup side effects manifest themselves both physically and behaviorally. Some dogs may exhibit personality changes, becoming nervous or aggressive. Others may experience vomiting or diarrhea, or develop neurological problems. These include seizures, tremors or disorientation. Because phenylpropanolamine raises the heart rate, your dog may experience rapid heartbeat and even collapse.


  • If your dog shows any of these side effects, stop giving her the medication and call your vet immediately.

Allergic Reactions

Some dogs may suffer allergic reactions to Propalin syrup. Signs of an allergic reaction include eyelid swelling, and a strong adverse reaction to bright light. Again, discontinue use of the medication and contact your vet if your dog shows any evidence of an allergic reaction.


In general, Propalin is used in spayed females. Do not use this medication on pregnant or nursing dogs. Dogs diagnosed with various conditions such not receive this drug. These include:

  • Cardiac disease or high blood pressure
  • Epilepsy
  • Kidney or liver disease, or diabetes mellitus
  • Glaucoma 

Tell your vet about any other medications or supplements your dog receives. Propalin syrup should not be given to dogs taking tricyclic antidepressants, nonsteroidal anti-inflammatories and anticholinergic drugs -- the latter sometimes prescribed for urinary incontinence.


  • Propalin syrup is only for use with dogs suffering a medical reason for urinary incontinence. It if it's a behavioral issue, your dog may require further training or the services of a veterinary therapist.

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