Tryptophan Side Effects
Tryptophan, more commonly known as L-tryptophan, is an herbal supplement that can be found in health food stores. Trytophan is used to combat insomnia, anxiety and depression. Tryptophan is not approved by the FDA in the United States because it's sold as an herbal or dietary supplement. Consult a doctor before using tryptophan if you have a health condition or take other medications, as it can cause side effects or interact with certain medications.
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Less Serious
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The less serious side effects of tryptophan that may occur include dry mouth, heartburn, burping and gas. Tryptophan could cause loss of appetite, headache, blurred vision, drowsiness, nausea, diarrhea or vomiting. If these side effects become bothersome, see a doctor and stop taking tryptophan.
Eosinophilia-Myalgia Syndrome
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Eosinophilia-Myalgia syndrome is a serious condition that appeared in 1989 in people who took tryptophan manufactured by a Japanese company. Eosinophilia-Myalgia Syndrome was caused by impure ingredients in the supplement. In recent years there have been no reported cases of EMS, but anyone taking tryptophan should know what the symptoms of EMS are and seek immediate emergency help if they occur. Purchasing tryptophan from sources outside the United States increase the risk of possible EMS.
The symptoms of EMS include severe muscle pain in the shoulders, back or legs; weakness, dryness, yellowing or hardening of the skin; swelling, heartbeat that is uneven, tremors, numbness, tingling or a burning pain that occurs mostly at night.
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Serotonin Syndrome
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The risk of serotonin syndrome increases if tryptophan is taken with prescription medications such as lithium, tramadol, migraine medications and antidepressants. This syndrome may also occur if the amount of tryptophan taken is increased. This is a very serious side effect and if any of these symptoms occur, seek emergency medical attention. The symptoms of serotonin syndrome include rapid heartbeat, loss of coordination, high fever, sweating, extreme anxiety, confusion, walking difficulties, strange thoughts, muscles twitching, nausea, vomiting, and diarrhea that is severe and will not stop.
Allergic Reaction
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Allergic reactions to tryptophan are rare. If any signs of an allergic reaction appear, 911 should be called immediately. The signs of an allergic reaction include hives, problems breathing; swelling of the tongue, face, lips or throat; dizziness, rash or itching.
Overdose
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As with any medication or supplement, overdose can occur if too much is taken. The symptoms of a tryptophan overdose include fever, agitation, restlessness, diarrhea, confusion, reflexes that are overactive, a lack of coordination, shivering, sweating, shaking and uncontrollable talking or excitement. Seek immediate medical attention if any of these symptoms appear.
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