- Proton pump inhibitors work by stopping the mechanism that pumps acid into the stomach. They are considered the superior medication for this purpose, and can be used to treat peptic ulcers, indigestion and gastro-esophageal reflux disease.
- Most PPIs are prescription medications such as Nexium. Omeprazole is a PPI that is available over the counter as Prilosec, as well as in generic store brands.
- While most doctors believe PPIs to have very few side effects, there are some conditions under which they should not be taken. PPIs raise the stomach's pH to a level that cannot absorb some medications, such as antibiotics. It also may affect the way a patient reacts to anti-anxiety drugs, anti-coagulants, and anti-convulsants.
- Some minor side effects have been experienced by patients taking proton pump inhibitors. These can include diarrhea, abdominal pain, headache, constipation, and nausea. There is some speculation as to whether PPIs raise the risk of stomach or esophageal cancer, but the research that has been done thus far generally disproves this.
- A recent study suggests that taking a PPI everyday for a year or more can increase bone loss and put the patient at risk for fractures. The numbers were higher for patients taking a double dose daily. Since most patients take only a single dose per day, doctors do not generally consider the risk high enough to recommend that their patients stop using PPIs. Taking the recommended dose is important to avoid these health risks.
- When taking PPIs it is a good idea to watch your diet and try to eat primarily foods that are easy to digest, especially when just starting out. You can adjust your diet as you see fit as you learn how the medication affects your digestion.
