The safest and most effective flea treatments are the preventatives available by prescription from a veterinarian, like Frontline, Advantage and Revolution. The active ingredient is either fipronil or imidacloprid, which quickly kills fleas and prevents further infestation. Other treatments, flea collars and flea shampoos are available in pet stores but are not as effective. Some use older-style pesticides like pyrethrins or organophosphates, which can be harmful and should never be used on small kittens, pregnant or nursing cats, or cats in ill health. Always check the label for active ingredients. Non-chemical remedies include flea combs and diatomaceous earth (DE). Used regularly, a flea comb will remove eggs and some fleas, but is not an effective control method when used alone. DE is a fine powder made from crushed algae, which has microscopic sharp pieces of grit that puncture the flea's hard outer body. It is very safe and effective for use in the environment and directly on a cat, although it does not kill fleas immediately.